Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering
Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic Review of Current Literature1
Section for
Clinical Oral Microbiology, Department of Odontology Cariology and Endodontics,
University of Copenhagen, DK-2200 Copenhagen, Denmark
2
Maxillofacial
Surgery & Implantology & Biomaterial Research Foundation, Tehran P.O.
Box 14155-6559, Iran 3 Department of Prosthodontics and Dental
Implantology, King Faisal University, Al-Ahsa 31982, Saudi Arabia
4
Center of
Excellence for Regenerative Dentistry, Department of Anatomy, Faculty of
Dentistry,
Chulalongkorn University,
Bangkok 10330, Thailand
5
Maxillofacial
Surgery & Implantology & Biomaterial Research Foundation, Isfahan P.O.
Box 61355-45, Iran
6
Oral, Head
& Neck Oncology and Microvascular Reconstructive Surgery, Department of
Oral and Maxillofacial Surgery, School of Dentistry, University of Texas Health
Science Center at Houston, Houston, TX 77030, USA
7
Department
of Biomedical and Electronic Engineering, School of Engineering, University of
Bradford, Bradford BD7 1DP, UK
* Correspondence:
f.sefat1@bradford.ac.ukAbstract: The current review
aimed to assess the reliability and efficacy of tissue-engineered composite
grafts in the reconstruction of large maxillofacial defects resulting from
trauma or a benign pathologic disease. A systematic review of the literature
was conducted using PubMed/Medline, Embase, and Scopus up to March 2022. The
eligibility criteria included patients who had been treated with composite
allogeneic tissue engineering for immediate/delayed reconstruction of large
maxillofacial defects with minimum/no bone harvesting site. In the initial
search, 2614 papers were obtained, and finally, 13 papers were eligible to be
included in the current study. Most included papers were case reports or case
series. A total of 144 cases were enrolled in this systematic review. The mean
age of the patients was 43.34 (age range: 9–89). Most studies reported a
successful outcome. Bone tissue engineering for the reconstruction and
regeneration of crucial-sized maxillofacial defects is an evolving science
still in its infancy. In conclusion, this review paper and the current
literature demonstrate the potential for using large-scale transplantable, vascularized,
and customizable bone with the aim of reconstructing the large maxillofacial
bony defects in short-term follow-ups.
Section for
Clinical Oral Microbiology, Department of Odontology Cariology and Endodontics,
University of Copenhagen, DK-2200 Copenhagen, Denmark
2
Maxillofacial
Surgery & Implantology & Biomaterial Research Foundation, Tehran P.O.
Box 14155-6559, Iran 3 Department of Prosthodontics and Dental
Implantology, King Faisal University, Al-Ahsa 31982, Saudi Arabia
4
Center of
Excellence for Regenerative Dentistry, Department of Anatomy, Faculty of
Dentistry,
Chulalongkorn University,
Bangkok 10330, Thailand
5
Maxillofacial
Surgery & Implantology & Biomaterial Research Foundation, Isfahan P.O.
Box 61355-45, Iran
6
Oral, Head
& Neck Oncology and Microvascular Reconstructive Surgery, Department of
Oral and Maxillofacial Surgery, School of Dentistry, University of Texas Health
Science Center at Houston, Houston, TX 77030, USA
7
Department
of Biomedical and Electronic Engineering, School of Engineering, University of
Bradford, Bradford BD7 1DP, UK
* Correspondence:
f.sefat1@bradford.ac.ukAbstract: The current review
aimed to assess the reliability and efficacy of tissue-engineered composite
grafts in the reconstruction of large maxillofacial defects resulting from
trauma or a benign pathologic disease. A systematic review of the literature
was conducted using PubMed/Medline, Embase, and Scopus up to March 2022. The
eligibility criteria included patients who had been treated with composite
allogeneic tissue engineering for immediate/delayed reconstruction of large
maxillofacial defects with minimum/no bone harvesting site. In the initial
search, 2614 papers were obtained, and finally, 13 papers were eligible to be
included in the current study. Most included papers were case reports or case
series. A total of 144 cases were enrolled in this systematic review. The mean
age of the patients was 43.34 (age range: 9–89). Most studies reported a
successful outcome. Bone tissue engineering for the reconstruction and
regeneration of crucial-sized maxillofacial defects is an evolving science
still in its infancy. In conclusion, this review paper and the current
literature demonstrate the potential for using large-scale transplantable, vascularized,
and customizable bone with the aim of reconstructing the large maxillofacial
bony defects in short-term follow-ups.
